Anti-NM23A antibody [ZN91] (STJA0033310)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenFull length human recombinant protein of human NME1 (NP_937818) produced in E.coli.
General Information
| Short Description | Mouse monoclonal anti-NM23A for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN91 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NME1 |
| Gene ID | 4830 |
| Uniprot ID | NDKA_HUMAN |
| Immunogen | Full length human recombinant protein of human NME1 (NP_937818) produced in E.coli. |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. |
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Protein Name | Nucleoside Diphosphate Kinase ANdk ANdp Kinase AGranzyme A-Activated DnaseGaadMetastasis Inhibition Factor Nm23Nm23-H1Tumor Metastatic Process-Associated Protein |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | CytoplasmNucleusCell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase A antibodyAnti-Ndk A antibodyAnti-Ndp Kinase A antibodyAnti-Granzyme A-Activated Dnase antibodyAnti-Gaad antibodyAnti-Metastasis Inhibition Factor Nm23 antibodyAnti-Nm23-H1 antibodyAnti-Tumor Metastatic Process-Associated Protein antibodyAnti-NME1 antibodyAnti-NDPKA antibodyAnti-NM23 antibody |
Information sourced from Uniprot.org