| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NACHT, LRR and PYD domains-containing protein 2 (620-700 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NLRP2 |
| Gene ID: | 55655 |
| Uniprot ID: | NALP2_HUMAN |
| Immunogen Region: | 620-700 aa |
| Specificity: | NALP2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 620-700 |
| Function | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 2Nucleotide-Binding Site Protein 1Pyrin Domain And Nacht Domain-Containing Protein 1Pyrin-Containing Apaf1-Like Protein 2 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 2 antibodyAnti-Nucleotide-Binding Site Protein 1 antibodyAnti-Pyrin Domain And Nacht Domain-Containing Protein 1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 2 antibodyAnti-NLRP2 antibodyAnti-NALP2 antibodyAnti-NBS1 antibodyAnti-PAN1 antibodyAnti-PYPAF2 antibody |
Information sourced from Uniprot.org