| Tissue Specificity | Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. |
| Post Translational Modifications | Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro. |
| Function | Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. |
| Protein Name | Nlr Family Card Domain-Containing Protein 4Card - Lrr - And Nacht-Containing ProteinCed-4-Like Protein ClanCaspase Recruitment Domain-Containing Protein 12Ice Protease-Activating FactorIpaf |
| Database Links | Reactome: R-HSA-6803207Reactome: R-HSA-844623 |
| Cellular Localisation | CytoplasmCytosolInflammasome |
| Alternative Antibody Names | Anti-Nlr Family Card Domain-Containing Protein 4 antibodyAnti-Card - Lrr - And Nacht-Containing Protein antibodyAnti-Ced-4-Like Protein Clan antibodyAnti-Caspase Recruitment Domain-Containing Protein 12 antibodyAnti-Ice Protease-Activating Factor antibodyAnti-Ipaf antibodyAnti-NLRC4 antibodyAnti-CARD12 antibodyAnti-CLAN antibodyAnti-CLAN1 antibodyAnti-IPAF antibodyAnti-UNQ6189 antibodyAnti-PRO20215 antibody |
Information sourced from Uniprot.org
