| Short Description : | Mouse monoclonal anti-Homeobox protein Nkx-3.1 (1-100 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ABT267 |
| Isotype: | IgG1k |
| Conjugation: | Unconjugated |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:200-400WB 1:200-1000 |
| Formulation: | Liquid in PBS pH7.2, 0.03% Proclin 300, with stabilizing protein. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX3-1 |
| Gene ID: | 4824 |
| Uniprot ID: | NKX31_HUMAN |
| Immunogen: | Synthesized peptide derived from the human NKX3.1 at the amino acid range 1-100 |
| Immunogen Region: | 1-100 aa |
| Specificity: | The antibody can specifically recognize human NKX3.1 protein. |
| Post Translational Modifications | Ubiquitinated by TOPORS.monoubiquitinated at several residues and also polyubiquitinated on single residues. |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGTAG-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Protein Name | Homeobox Protein Nkx-3.1Homeobox Protein Nk-3 Homolog A |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.1 antibodyAnti-Homeobox Protein Nk-3 Homolog A antibodyAnti-NKX3-1 antibodyAnti-NKX3.1 antibodyAnti-NKX3A antibody |
Information sourced from Uniprot.org
