Western blot analysis using Nkx-2.5 monoclonal antibody against full-length NKX2.5 (aa1-324) -hIgGFc transfected HEK293 cell lysate (1).

Anti-NKX2-5 antibody [2E1] (STJ98278)

SKU:
STJ98278
£144.00 - £348.00
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Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Homeobox protein Nkx-2.5 is suitable for use in Western Blot and ELISA research applications.
Clonality : Monoclonal
Clone ID : 2E1
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in 0.01M PBS pH7.4 containing 0.03% Sodium Azide.
Purification: Antibody are purified by protein G affinity chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NKX2-5
Gene ID: 1482
Uniprot ID: NKX25_HUMAN
Specificity: Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.
Immunogen: Purified recombinant fragment of human Nkx-2.5 expressed in E. Coli.
Function Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia.
Protein Name Homeobox Protein Nkx-2.5
Cardiac-Specific Homeobox
Homeobox Protein Csx
Homeobox Protein Nk-2 Homolog E
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-5578768
Reactome: R-HSA-9733709
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Nkx-2.5 antibody
Anti-Cardiac-Specific Homeobox antibody
Anti-Homeobox Protein Csx antibody
Anti-Homeobox Protein Nk-2 Homolog E antibody
Anti-NKX2-5 antibody
Anti-CSX antibody
Anti-NKX2.5 antibody
Anti-NKX2E antibody

Information sourced from Uniprot.org

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