| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NKX2-5 (1-135) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NKX2-5 |
| Gene ID: |
1482 |
| Uniprot ID: |
NKX25_HUMAN |
| Immunogen Region: |
1-135 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human NKX2-5 (NP_004378.1). |
| Immunogen Sequence: |
MFPSPALTPTPFSVKDILNL EQQQRSLAAAGELSARLEAT LAPSSCMLAAFKPEAYAGPE AAAPGLPELRAELGRAPSPA KCASAFPAAPAFYPRAYSDP DPAKDPRAEKKELCALQKAV ELEKTEADNAERPRA |
| Tissue Specificity | Expressed only in the heart. |
| Function | Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia. |
| Protein Name | Homeobox Protein Nkx-2.5Cardiac-Specific HomeoboxHomeobox Protein CsxHomeobox Protein Nk-2 Homolog E |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-5578768Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.5 antibodyAnti-Cardiac-Specific Homeobox antibodyAnti-Homeobox Protein Csx antibodyAnti-Homeobox Protein Nk-2 Homolog E antibodyAnti-NKX2-5 antibodyAnti-CSX antibodyAnti-NKX2.5 antibodyAnti-NKX2E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
