| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NKRF (391-690) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NKRF |
| Gene ID: |
55922 |
| Uniprot ID: |
NKRF_HUMAN |
| Immunogen Region: |
391-690 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human NKRF (NP_060014.2). |
| Immunogen Sequence: |
YGTKKTSKHAAADEALKILQ KTQPTYPSVKSSQCHTGSSP RGSGKKKDIKDLVVYENSSN PVCTLNDTAQFNRMTVEYVY ERMTGLRWKCKVILESEVIA EAVGVKKTVKYEAAGEAVKT LKKTQPTVINNLKKGAVEDV ISRNEIQGRSAEEAYKQQIK EDNIGNQLLRKMGWTGGGLG KSGEGIREPISVKEQHKREG LGLDVERVNKIAKRDIEQII RNYARSESHTDLTFSRELT |
| Tissue Specificity | Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney. |
| Function | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. |
| Protein Name | Nf-Kappa-B-Repressing FactorNfkb-Repressing FactorNrfProtein Itba4 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Nf-Kappa-B-Repressing Factor antibodyAnti-Nfkb-Repressing Factor antibodyAnti-Nrf antibodyAnti-Protein Itba4 antibodyAnti-NKRF antibodyAnti-ITBA4 antibodyAnti-NRF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
