Anti-NKRF antibody (391-690) (STJ24770)

Name: Anti-NKRF antibody (391-690) (STJ24770)
SKU: STJ24770
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ24770

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Short Description	Rabbit polyclonal NKRF (391-690) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NKRF
Gene ID	55922
Uniprot ID	NKRF_HUMAN
Immunogen Region	391-690
Immunogen Sequence	YGTKKTSKHAAADEALKILQ KTQPTYPSVKSSQCHTGSSP RGSGKKKDIKDLVVYENSSN PVCTLNDTAQFNRMTVEYVY ERMTGLRWKCKVILESEVIA EAVGVKKTVKYEAAGEAVKT LKKTQPTVINNLKKGAVEDV ISRNEIQGRSAEEAYKQQIK EDNIGNQLLRKMGWTGGGLG KSGEGIREPISVKEQHKREG LGLDVERVNKIAKRDIEQII RNYARSESHTDLTFSRELT
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 391-690 of human NKRF (NP_060014.2).

Tissue Specificity	Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
Function	Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes.
Protein Name	Nf-Kappa-B-Repressing Factor Nfkb-Repressing Factor Nrf Protein Itba4
Database Links
Cellular Localisation	Nucleus Nucleolus
Alternative Antibody Names	Anti-Nf-Kappa-B-Repressing Factor antibody Anti-Nfkb-Repressing Factor antibody Anti-Nrf antibody Anti-Protein Itba4 antibody Anti-NKRF antibody Anti-ITBA4 antibody Anti-NRF antibody

Information sourced from Uniprot.org