Anti-NKG2D antibody (180-230) {FITC} (STJ501926)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 180-230 on rat NKG2D protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-NKG2D (180-230) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Bovine/Human/Monkey/Panda |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.55 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Klrk1 |
| Gene ID | 24934 |
| Uniprot ID | NKG2D_RAT |
| Immunogen | Synthetic peptide taken within amino acid region 180-230 on rat NKG2D protein. |
| Immunogen Region | 180-230 |
Additional Info
| Tissue Specificity | Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells. |
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNk Lectin-Like ReceptorNkllrNkg2-D-Activating Nk ReceptorNkr-P2Cd Antigen Cd314 |
| Database Links | Reactome: R-RNO-198933Reactome: -RNO-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst On The Cell Surface |
| Alternative Antibody Names | Anti-Nkg2-D Type Ii Integral Membrane Protein antibodyAnti-Killer Cell Lectin-Like Receptor Subfamily K Member 1 antibodyAnti-Nk Cell Receptor D antibodyAnti-Nk Lectin-Like Receptor antibodyAnti-Nkllr antibodyAnti-Nkg2-D-Activating Nk Receptor antibodyAnti-Nkr-P2 antibodyAnti-Cd Antigen Cd314 antibodyAnti-Klrk1 antibodyAnti-Nkg2d antibodyAnti-Nkrp2 antibody |
Information sourced from Uniprot.org