| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein naked cuticle homolog 2 (311-361 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKD2 |
| Gene ID: | 85409 |
| Uniprot ID: | NKD2_HUMAN |
| Immunogen Region: | 311-361 aa |
| Specificity: | This antibody detects endogenous levels of NKD2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human NKD2 at the amino acid range 311-361 |
| Post Translational Modifications | Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25. |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. |
| Protein Name | Protein Naked Cuticle Homolog 2Naked-2Hnkd2 |
| Cellular Localisation | Cell MembraneCytoplasmCytoplasmic Vesicle |
| Alternative Antibody Names | Anti-Protein Naked Cuticle Homolog 2 antibodyAnti-Naked-2 antibodyAnti-Hnkd2 antibodyAnti-NKD2 antibody |
Information sourced from Uniprot.org