Anti-NIT1 antibody (32-82 aa) (STJ195527)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human NIT1 at the amino acid range 32-82
General Information
| Short Description | Rabbit polyclonal anti-Deaminated glutathione amidase (32-82 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NIT1 |
| Gene ID | 4817 |
| Uniprot ID | NIT1_HUMAN |
| Immunogen | Synthesized peptide derived from the human NIT1 at the amino acid range 32-82 |
| Immunogen Region | 32-82 aa |
| Specificity | This antibody detects endogenous levels of NIT1 at Human/Mouse/Rat |
Additional Info
| Function | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
| Protein Name | Deaminated Glutathione AmidaseDgsh AmidaseNitrilase Homolog 1 |
| Database Links | |
| Cellular Localisation | Isoform 2: MitochondrionIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Deaminated Glutathione Amidase antibodyAnti-Dgsh Amidase antibodyAnti-Nitrilase Homolog 1 antibodyAnti-NIT1 antibody |
Information sourced from Uniprot.org