| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Deaminated glutathione amidase (32-82 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NIT1 |
| Gene ID: | 4817 |
| Uniprot ID: | NIT1_HUMAN |
| Immunogen Region: | 32-82 aa |
| Specificity: | This antibody detects endogenous levels of NIT1 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human NIT1 at the amino acid range 32-82 |
| Function | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
| Protein Name | Deaminated Glutathione AmidaseDgsh AmidaseNitrilase Homolog 1 |
| Cellular Localisation | Isoform 2: MitochondrionIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Deaminated Glutathione Amidase antibodyAnti-Dgsh Amidase antibodyAnti-Nitrilase Homolog 1 antibodyAnti-NIT1 antibody |
Information sourced from Uniprot.org
