| Tissue Specificity | Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. |
| Post Translational Modifications | May be inactivated by phosphorylation on Ser-199 or Ser-204. Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA. |
| Function | Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. |
| Protein Name | Nuclear Inhibitor Of Protein Phosphatase 1Nipp-1Protein Phosphatase 1 Regulatory Inhibitor Subunit 8 Includes - Activator Of Rna DecayArd-1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpecklePrimarilyBut Not ExclusivelyNuclearIsoform Gamma: CytoplasmFound Mainly In The Cytoplasm |
| Alternative Antibody Names | Anti-Nuclear Inhibitor Of Protein Phosphatase 1 antibodyAnti-Nipp-1 antibodyAnti-Protein Phosphatase 1 Regulatory Inhibitor Subunit 8 Includes - Activator Of Rna Decay antibodyAnti-Ard-1 antibodyAnti-PPP1R8 antibodyAnti-ARD1 antibodyAnti-NIPP1 antibody |
Information sourced from Uniprot.org
