Anti-NINL antibody (1098-1148) (STJA0006480)

SKU:
STJA0006480

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ninein-like protein (1098-1148) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NINL
Gene ID: 22981
Uniprot ID: NINL_HUMAN
Immunogen Region: 1098-1148
Specificity: This antibody detects endogenous levels of human NINL
Immunogen: Synthesized peptide derived from human NINL AA range: 1098-1148
Post Translational Modifications Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin. Ubiquitinated by the APC/C complex leading to its degradation.
Function Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery.it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells. May play a role in ovarian carcinogenesis.
Protein Name Ninein-Like Protein
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
In Interphase Cells
Ninl Is Transported To The Centrosomes By The Dynein-Dynactin Motor Complex
During Centrosome Maturation
Plk1 Directly Phosphorylates Ninl Resulting In Its Release Into The Cytoplasm
Alternative Antibody Names Anti-Ninein-Like Protein antibody
Anti-NINL antibody
Anti-KIAA0980 antibody
Anti-NLP antibody

Information sourced from Uniprot.org

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