| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ninein-like protein (1098-1148) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NINL |
| Gene ID: |
22981 |
| Uniprot ID: |
NINL_HUMAN |
| Immunogen Region: |
1098-1148 |
| Specificity: |
This antibody detects endogenous levels of human NINL |
| Immunogen: |
Synthesized peptide derived from human NINL AA range: 1098-1148 |
| Post Translational Modifications | Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin. Ubiquitinated by the APC/C complex leading to its degradation. |
| Function | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery.it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells. May play a role in ovarian carcinogenesis. |
| Protein Name | Ninein-Like Protein |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeIn Interphase CellsNinl Is Transported To The Centrosomes By The Dynein-Dynactin Motor ComplexDuring Centrosome MaturationPlk1 Directly Phosphorylates Ninl Resulting In Its Release Into The Cytoplasm |
| Alternative Antibody Names | Anti-Ninein-Like Protein antibodyAnti-NINL antibodyAnti-KIAA0980 antibodyAnti-NLP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
