| Short Description : | Rabbit polyclonal antibody anti-Nicotinic Acetylcholine Receptor alpha 7 (7-2) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications: | ELISA/IP/WB |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Biotin |
| Concentration: | 0.75-0.95 µg/µl |
| Purification: | Affinity Purified |
| Dilution Range: | WB: 1:250DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Chrna7 |
| Gene ID: | 25302 |
| Uniprot ID: | ACHA7_RAT |
| Immunogen: | Synthetic peptide corresponding to exon 5 of alpha 7-2 nAChRs protein. |
| Immunogen Region: | 7-2 |
| Post Translational Modifications | Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane. |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-7 |
| Database Links | Reactome: R-RNO-629594 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneRic3 Promotes Its Trafficking To The Cell MembraneTmem35a/Nacho Promotes Its Trafficking To The Cell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-7 antibodyAnti-Chrna7 antibodyAnti-Acra7 antibody |
Information sourced from Uniprot.org
