| Short Description : | Rabbit polyclonal anti-NELL2-interacting cell ontogeny regulator 1 (24-74 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NICOL1 |
| Gene ID: | 401115 |
| Uniprot ID: | NICOL_HUMAN |
| Immunogen: | Synthesized peptide derived from the human CD048 at the amino acid range 24-74 |
| Immunogen Region: | 24-74 aa |
| Specificity: | This antibody detects endogenous levels of CD048 at Human/Mouse |
| Function | mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2. Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. |
| Protein Name | Nell2-Interacting Cell Ontogeny Regulator 1Nell2-Interacting Cofactor For Lumicrine SignalingNicol |
| Database Links | |
| Cellular Localisation | SecretedCytoplasmPerinuclear RegionDetected In The Perinuclear Region Of Fibroblasts |
| Alternative Antibody Names | Anti-Nell2-Interacting Cell Ontogeny Regulator 1 antibodyAnti-Nell2-Interacting Cofactor For Lumicrine Signaling antibodyAnti-Nicol antibodyAnti-NICOL1 antibodyAnti-C4orf48 antibody |
Information sourced from Uniprot.org
