| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase NHLRC1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NHLRC1 |
| Gene ID: |
378884 |
| Uniprot ID: |
NHLC1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of NHLRC1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human NHLRC1 |
| Function | E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. |
| Protein Name | E3 Ubiquitin-Protein Ligase Nhlrc1MalinNhl Repeat-Containing Protein 1Ring-Type E3 Ubiquitin Transferase Nhlrc1 |
| Database Links | Reactome: R-HSA-3322077Reactome: R-HSA-3785653 |
| Cellular Localisation | Endoplasmic ReticulumNucleusLocalizes At The Endoplasmic Reticulum AndTo A Lesser ExtentIn The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Nhlrc1 antibodyAnti-Malin antibodyAnti-Nhl Repeat-Containing Protein 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nhlrc1 antibodyAnti-NHLRC1 antibodyAnti-EPM2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
