| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-NGFRAP1 (C-Term) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Preliminary experiments in Human Liver, Ovary, Prostate and Testis lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | BEX3 |
| Gene ID: | 27018 |
| Uniprot ID: | BEX3_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_996800.1; NP_996798.1; NP_055195.1 |
| Specificity: | This antibody is expected to recognise isoform a (NP_996800.1) and isoform b (NP_996798.1 and NP_055195.1). |
| Immunogen Sequence: | CLRILMGELSNHHDH |
| Post Translational Modifications | Ubiquitinated. Degraded by the proteasome. |
| Function | May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
| Protein Name | Protein Bex3Brain-Expressed X-Linked Protein 3Nerve Growth Factor Receptor-Associated Protein 1Ovarian Granulosa Cell 13.0 Kda Protein Hgr74P75ntr-Associated Cell Death Executor |
| Database Links | Reactome: R-HSA-205025 |
| Cellular Localisation | NucleusCytoplasmCytosolShuttles Between The Cytoplasm And The NucleusAssociates With Replicating Mitochondria |
| Alternative Antibody Names | Anti-Protein Bex3 antibodyAnti-Brain-Expressed X-Linked Protein 3 antibodyAnti-Nerve Growth Factor Receptor-Associated Protein 1 antibodyAnti-Ovarian Granulosa Cell 13.0 Kda Protein Hgr74 antibodyAnti-P75ntr-Associated Cell Death Executor antibodyAnti-BEX3 antibodyAnti-DXS6984E antibodyAnti-NADE antibodyAnti-NGFRAP1 antibody |
Information sourced from Uniprot.org