Anti-NGFR antibody (300-400) [S5MR] (STJ11101625)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal NGFR (300-400) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:4000-1:16000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NGFR |
| Gene ID | 4804 |
| Uniprot ID | TNR16_HUMAN |
| Immunogen Region | 300-400 |
| Immunogen Sequence | KLHSDSGISVDSQSLHDQQP HTQTASGQALKGDGGLYSSL PPAKREEVEKLLNGSAGDTW RHLAGELGYQPEHIDSFTHE ACPVRALLASWATQDSATLD A |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human p75 NGF Receptor (P08138). |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues. |
| Function | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 16Gp80-LngfrLow Affinity Neurotrophin Receptor P75ntrLow-Affinity Nerve Growth Factor ReceptorNgf ReceptorLow-Affinity Nerve Growth Factor Receptor P75ngfrLow-Affinity Nerve Growth Factor Receptor P75ngrP75 IcdCd Antigen Cd271 |
| Database Links | Reactome: R-HSA-193634Reactome: R-HSA-193648Reactome: R-HSA-193670Reactome: R-HSA-193681Reactome: R-HSA-193692Reactome: R-HSA-205017Reactome: R-HSA-205025Reactome: R-HSA-205043Reactome: R-HSA-209543Reactome: R-HSA-209560Reactome: R-HSA-209563 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionGrowth ConeDendritic Spine |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 16 antibodyAnti-Gp80-Lngfr antibodyAnti-Low Affinity Neurotrophin Receptor P75ntr antibodyAnti-Low-Affinity Nerve Growth Factor Receptor antibodyAnti-Ngf Receptor antibodyAnti-Low-Affinity Nerve Growth Factor Receptor P75ngfr antibodyAnti-Low-Affinity Nerve Growth Factor Receptor P75ngr antibodyAnti-P75 Icd antibodyAnti-Cd Antigen Cd271 antibodyAnti-NGFR antibodyAnti-TNFRSF16 antibody |
Information sourced from Uniprot.org