Anti-NFKBIE antibody (140-280) (STJ110741)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NFKBIE (140-280) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NFKBIE |
| Gene ID | 4794 |
| Uniprot ID | IKBE_HUMAN |
| Immunogen Region | 140-280 |
| Immunogen Sequence | MSEARKGPDEAEESQYDSGI ESLRSLRSLPESTSAPASGP SDGSPQPCTHPPGPVKEPQE KEDADGERADSTYGSSSLTY TLSLLGGPEAEDPAPRLPLP HVGALSPQQLEALTYISEDG DTLVHLAVIHEAPAVLLCCL A |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human NFKBIE (NP_004547.2). |
Additional Info
| Tissue Specificity | Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
| Post Translational Modifications | Serine phosphorylated.followed by proteasome-dependent degradation. |
| Function | Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development. |
| Protein Name | Nf-Kappa-B Inhibitor EpsilonNf-Kappa-BieI-Kappa-B-EpsilonIkb-EIkb-EpsilonIkappabepsilon |
| Database Links | Reactome: R-HSA-1169091 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Epsilon antibodyAnti-Nf-Kappa-Bie antibodyAnti-I-Kappa-B-Epsilon antibodyAnti-Ikb-E antibodyAnti-Ikb-Epsilon antibodyAnti-Ikappabepsilon antibodyAnti-NFKBIE antibodyAnti-IKBE antibody |
Information sourced from Uniprot.org