| Post Translational Modifications | Phosphorylated. Phosphorylated at Thr-135 by CDK5 in response to osmotic stress.this phosphorylation mediates its rapid nuclear localization. Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage. |
| Function | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-ACTAGTGGAAACATATAATCCAATGGTGACCGCT-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes.optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops.R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. |
| Protein Name | Nuclear Factor Of Activated T-Cells 5Nf-At5T-Cell Transcription Factor Nfat5Tonicity-Responsive Enhancer-Binding ProteinTone-Binding ProteinTonebp |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmChromosomeNuclear Distribution Increases Under Hypertonic ConditionsRecruited To Sites Of R-Loop-Associated Dna Damage Following Poly-Adp-Ribosylation By Parp1 |
| Alternative Antibody Names | Anti-Nuclear Factor Of Activated T-Cells 5 antibodyAnti-Nf-At5 antibodyAnti-T-Cell Transcription Factor Nfat5 antibodyAnti-Tonicity-Responsive Enhancer-Binding Protein antibodyAnti-Tone-Binding Protein antibodyAnti-Tonebp antibodyAnti-NFAT5 antibodyAnti-KIAA0827 antibodyAnti-TONEBP antibody |
Information sourced from Uniprot.org
