Anti-NF1 antibody (1551-1600) (STJ94430)

Name: Anti-NF1 antibody (1551-1600) (STJ94430)
SKU: STJ94430
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenThe antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600

STJ94430

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Short Description	Rabbit polyclonal anti-Neurofibromin (1551-1600) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range	WB 1:500-2000 IHC-p 1:50-300
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NF1
Gene ID	4763
Uniprot ID	NF1_HUMAN
Immunogen	The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600
Immunogen Region	1551-1600
Specificity	Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein.

Tissue Specificity	Detected in brain, peripheral nerve, lung, colon and muscle.
Post Translational Modifications	Ubiquitinated by RNF7/RBX2, leading to its degradation.
Function	Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Protein Name	Neurofibromin Neurofibromatosis-Related Protein Nf-1 Cleaved Into - Neurofibromin Truncated
Database Links	Reactome: R-HSA-5658442 Reactome: R-HSA-6802953
Cellular Localisation	Nucleus Nucleolus Cell Membrane
Alternative Antibody Names	Anti-Neurofibromin antibody Anti-Neurofibromatosis-Related Protein Nf-1 Cleaved Into - Neurofibromin Truncated antibody Anti-NF1 antibody

Information sourced from Uniprot.org