| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Neurofibromin (1551-1600) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NF1 |
| Gene ID: | 4763 |
| Uniprot ID: | NF1_HUMAN |
| Immunogen Region: | 1551-1600 |
| Specificity: | Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600 |
| Tissue Specificity | Detected in brain, peripheral nerve, lung, colon and muscle. |
| Post Translational Modifications | Ubiquitinated by RNF7/RBX2, leading to its degradation. |
| Function | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. |
| Protein Name | NeurofibrominNeurofibromatosis-Related Protein Nf-1 Cleaved Into - Neurofibromin Truncated |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-6802953 |
| Cellular Localisation | NucleusNucleolusCell Membrane |
| Alternative Antibody Names | Anti-Neurofibromin antibodyAnti-Neurofibromatosis-Related Protein Nf-1 Cleaved Into - Neurofibromin Truncated antibodyAnti-NF1 antibody |
Information sourced from Uniprot.org