| Tissue Specificity | Bone marrow cells. Neutrophil. |
| Function | Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro.digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. |
| Protein Name | Neutrophil ElastaseBone Marrow Serine ProteaseElastase-2Human Leukocyte ElastaseHleMedullasinPmn Elastase |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-5620971Reactome: R-HSA-6798695Reactome: R-HSA-6803157Reactome: R-HSA-977606Reactome: R-HSA-9911233 |
| Cellular Localisation | Cytoplasmic VesiclePhagosomeLocalized In Phagolysosomes Following Ingestion Of EColi By Neutrophils |
| Alternative Antibody Names | Anti-Neutrophil Elastase antibodyAnti-Bone Marrow Serine Protease antibodyAnti-Elastase-2 antibodyAnti-Human Leukocyte Elastase antibodyAnti-Hle antibodyAnti-Medullasin antibodyAnti-Pmn Elastase antibodyAnti-ELANE antibodyAnti-ELA2 antibody |
Information sourced from Uniprot.org
