| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-Neurturin for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 1B11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS pH 7.4, with 0.1% sodium azide |
| Purification: | IgG |
| Dilution Range: | WB 1:5000-1:10000 |
| Storage Instruction: | Store at-20°C or-70°C upon receipt. After opening divide antibody into smaller aliquots and store at-20°C or-70°C for up to six months. Avoid multiple freeze-thaw cycles as product degradation may result. |
| Gene Symbol: | NRTN |
| Gene ID: | 4902 |
| Uniprot ID: | NRTN_HUMAN |
| Specificity: | Human NTN (Neurturin). |
| Immunogen: | Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant. |
| Immunogen Sequence: | Human |
| Function | Growth factor that supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Involved in the development of the neural crest. Might control the size of non-neuronal cell population such as haemopoietic cells. Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor. Heparan sulfate-binding is required for signaling. |
| Protein Name | Neurturin |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neurturin antibodyAnti-NRTN antibody |
Information sourced from Uniprot.org
