| Short Description : | Rabbit polyclonal anti-Neurokinin-3 Receptor (C-Term) for use in WB in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | Mixed |
| Conjugation: | Unconjugated |
| Purification: | Whole serum |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | Tacr3 |
| Gene ID: | 24808 |
| Uniprot ID: | NK3R_RAT |
| Immunogen: | A synthetic peptide (ASTTSSF ISSPYTSVDE YS) corresponding to the absolute C-terminal of rat NK-3 receptor protein (aa: 434-452) conjugated to KLH |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | Rat |
| Specificity: | Specificity has been shown by Western blot using rat brain homogenate. A band of 66 kDa, the theoretical MW of NK-3R, could be easily detected. This antiserum is know to cross react with rat NK-3 R. |
| Post Translational Modifications | The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. |
| Function | This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. |
| Protein Name | Neuromedin-K ReceptorNkrNk-3 ReceptorNk-3rNeurokinin B ReceptorTachykinin Receptor 3 |
| Database Links | Reactome: R-RNO-380095Reactome: -RNO-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Neuromedin-K Receptor antibodyAnti-Nkr antibodyAnti-Nk-3 Receptor antibodyAnti-Nk-3r antibodyAnti-Neurokinin B Receptor antibodyAnti-Tachykinin Receptor 3 antibodyAnti-Tacr3 antibodyAnti-Tac3r antibody |
Information sourced from Uniprot.org
