| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Neurochondrin (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
NCDN |
| Gene ID: |
23154 |
| Uniprot ID: |
NCDN_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_055099.1; NP_001014841.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_055099.1; NP_001014841.1). Reported variants represent identical protein (NP_055099.1; NP_001014839.1). |
| Immunogen Sequence: |
HYLLQVGSEKQKEP |
| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. |
| Function | Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable). |
| Protein Name | Neurochondrin |
| Cellular Localisation | CytoplasmCytosolEndosome MembraneLipid-AnchorCell ProjectionDendritePostsynapseLocalizes To Somatic Regions Of NeuronsLocalization To Endosome Membrane Requires Palmitoylation |
| Alternative Antibody Names | Anti-Neurochondrin antibodyAnti-NCDN antibodyAnti-KIAA0607 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
