Host: | Mouse |
Applications: | WB/IHC/ICC |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-Nestin is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
Clonality : | Monoclonal |
Clone ID : | 4D11 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide |
Purification: | This antibody was protein g purified culture from supernatant. |
Dilution Range: | WB 1:2000IHC 1:500ICC 1:500 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | NES |
Gene ID: | 10763 |
Uniprot ID: | NEST_HUMAN |
Immunogen: | Recombinant human Nestin expressed in and purifeid from E. coli. |
Tissue Specificity | CNS stem cells. |
Post Translational Modifications | Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. |
Protein Name | Nestin |
Alternative Antibody Names | Anti-Nestin antibodyAnti-NES antibodyAnti-Nbla00170 antibody |
Information sourced from Uniprot.org