| Host: | Mouse |
| Applications: | WB/IHC/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Nestin is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 4D11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide |
| Purification: | This antibody was protein g purified culture from supernatant. |
| Dilution Range: | WB 1:2000IHC 1:500ICC 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NES |
| Gene ID: | 10763 |
| Uniprot ID: | NEST_HUMAN |
| Immunogen: | Recombinant human Nestin expressed in and purifeid from E. coli. |
| Tissue Specificity | CNS stem cells. |
| Post Translational Modifications | Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
| Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. |
| Protein Name | Nestin |
| Alternative Antibody Names | Anti-Nestin antibodyAnti-NES antibodyAnti-Nbla00170 antibody |
Information sourced from Uniprot.org
![Anti-CRASH antibody [4D11] (STJ16101067)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149783/302532/STJ16101067_1__06267.1646940690.jpg?c=1 "Anti-CRASH antibody [4D11] (STJ16101067)")
