| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
NELFA |
| Gene ID: |
7469 |
| Uniprot ID: |
NELFA_HUMAN |
| Immunogen Region: |
300-539 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-539 of human NELFA (NP_005654.3). |
| Immunogen Sequence: |
EETVVENATPDYAAGLVSTQ KLGSLNNEPALPSTSYLPST PSVVPASSYIPSSETPPAPS SREASRPPEEPSAPSPTLPA QFKQRAPMYNSGLSPATPTP AAPTSPLTPTTPPAVAPTTQ TPPVAMVAPQTQAPAQQQPK KNLSLTREQMFAAQEMFKTA NKVTRPEKALILGFMAGSRE NPCQEQGDVIQIKLSEHTED LPKADGQGSTTMLVDTVFEM NYATGQWTRFKKYKPMTNV |
| Tissue Specificity | Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney. |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. |
| Protein Name | Negative Elongation Factor ANelf-AWolf-Hirschhorn Syndrome Candidate 2 Protein |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Negative Elongation Factor A antibodyAnti-Nelf-A antibodyAnti-Wolf-Hirschhorn Syndrome Candidate 2 Protein antibodyAnti-NELFA antibodyAnti-WHSC2 antibodyAnti-P antibodyAnti-OKcl.15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
