| Tissue Specificity | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts. |
| Post Translational Modifications | Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro. |
| Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. |
| Protein Name | Serine/Threonine-Protein Kinase Nek9Nercc1 KinaseNever In Mitosis A-Related Kinase 9Nima-Related Protein Kinase 9Nima-Related Kinase 8Nek8 |
| Database Links | Reactome: R-HSA-2980767Reactome: R-HSA-3301854Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek9 antibodyAnti-Nercc1 Kinase antibodyAnti-Never In Mitosis A-Related Kinase 9 antibodyAnti-Nima-Related Protein Kinase 9 antibodyAnti-Nima-Related Kinase 8 antibodyAnti-Nek8 antibodyAnti-NEK9 antibodyAnti-KIAA1995 antibodyAnti-NEK8 antibodyAnti-NERCC antibody |
Information sourced from Uniprot.org
