Anti-NEK3 antibody (267-506) (STJ28748)

Name: Anti-NEK3 antibody (267-506) (STJ28748)
SKU: STJ28748
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ28748

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Short Description	Rabbit polyclonal NEK3 (267-506) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NEK3
Gene ID	4752
Uniprot ID	NEK3_HUMAN
Immunogen Region	267-506
Immunogen Sequence	PEIIMEYGEEVLEEIKNSKH NTPRKKTNPSRIRIALGNEA STVQEEEQDRKGSHTDLESI NENLVESALRRVNREEKGNK SVHLRKASSPNLHRRQWEKN VPNTALTALENASILTSSLT AEDDRGGSVIKYSKNTTRKQ WLKETPDTLLNILKNADLSL AFQTYTIYRPGSEGFLKGPL SEETEASDSVDGGHDSVILD PERLEPGLDEEDTDFEEEDD NPDWVSELKKRAGWQGLCD
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 267-506 of human NEK3 (NP_689933.1).

Tissue Specificity	Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
Post Translational Modifications	Phosphorylation at Thr-479 regulates its catalytic activity.
Function	Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
Protein Name	Serine/Threonine-Protein Kinase Nek3 Hspk 36 Never In Mitosis A-Related Kinase 3 Nima-Related Protein Kinase 3
Database Links
Cellular Localisation	Cytoplasm Cell Projection Axon
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Nek3 antibody Anti-Hspk 36 antibody Anti-Never In Mitosis A-Related Kinase 3 antibody Anti-Nima-Related Protein Kinase 3 antibody Anti-NEK3 antibody

Information sourced from Uniprot.org