| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEIL1 |
| Gene ID: |
79661 |
| Uniprot ID: |
NEIL1_HUMAN |
| Immunogen Region: |
1-135 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human NEIL1 (NP_078884.2). |
| Immunogen Sequence: |
MPEGPELHLASQFVNEACRA LVFGGCVEKSSVSRNPEVPF ESSAYRISASARGKELRLIL SPLPGAQPQQEPLALVFRFG MSGSFQLVPREELPRHAHLR FYTAPPGPRLALCFVDIRRF GRWDLGGKWQPGRGP |
| Tissue Specificity | Ubiquitous. |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. |
| Protein Name | Endonuclease 8-Like 1Dna Glycosylase/Ap Lyase Neil1Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1Endonuclease Viii-Like 1Fpg1Nei Homolog 1Neh1Nei-Like Protein 1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702Reactome: R-HSA-9616334 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusChromosomeDuring MitosisAssociates With Centrosomes And Condensed Chromatin |
| Alternative Antibody Names | Anti-Endonuclease 8-Like 1 antibodyAnti-Dna Glycosylase/Ap Lyase Neil1 antibodyAnti-Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1 antibodyAnti-Endonuclease Viii-Like 1 antibodyAnti-Fpg1 antibodyAnti-Nei Homolog 1 antibodyAnti-Neh1 antibodyAnti-Nei-Like Protein 1 antibodyAnti-NEIL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
