| Host: |
Mouse |
| Applications: |
WB/IHC/ICC |
| Reactivity: |
Bovine/Chicken/Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Mouse monoclonal antibody anti-NEFL/NF-L is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
DA2 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
100 ul in PBS + 10 mM Sodium Azide. |
| Purification: |
This antibody was protein g purified culture from supernatant. |
| Dilution Range: |
WB 1:1000IHC 1:100-1:1000ICC 1:100-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEFL |
| Gene ID: |
4747 |
| Uniprot ID: |
NFL_HUMAN |
| Immunogen: |
Preparation of porcine NF-L. |
| Post Translational Modifications | O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1. |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. |
| Protein Name | Neurofilament Light PolypeptideNf-L68 Kda Neurofilament ProteinNeurofilament Triplet L Protein |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell ProjectionAxonCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Neurofilament Light Polypeptide antibodyAnti-Nf-L antibodyAnti-68 Kda Neurofilament Protein antibodyAnti-Neurofilament Triplet L Protein antibodyAnti-NEFL antibodyAnti-NF68 antibodyAnti-NFL antibody |
Information sourced from Uniprot.org
