Anti-NECTIN4 antibody (312-361) (STJ94390)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361
General Information
| Short Description | Rabbit polyclonal anti-Nectin-4 (312-361) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NECTIN4 |
| Gene ID | 81607 |
| Uniprot ID | NECT4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PVRL4. AA range:312-361 |
| Immunogen Region | 312-361 |
| Specificity | Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein. |
Additional Info
| Tissue Specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
| Post Translational Modifications | The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. |
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus. |
| Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens JunctionsProcessed Poliovirus Receptor-Related Protein 4: SecretedThe Secreted Form Is Found In Breast Tumor Patients |
| Alternative Antibody Names | Anti-Nectin-4 antibodyAnti-Ig Superfamily Receptor Lnir antibodyAnti-Nectin Cell Adhesion Molecule 4 antibodyAnti-Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 antibodyAnti-NECTIN4 antibodyAnti-LNIR antibodyAnti-PRR4 antibodyAnti-PVRL4 antibody |
Information sourced from Uniprot.org