Anti-NECTIN2 antibody (410-538) [S9MR] (STJ11102509)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Nectin 2/CD112 (410-538) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NECTIN2 |
| Gene ID | 5819 |
| Uniprot ID | NECT2_HUMAN |
| Immunogen Region | 410-538 |
| Immunogen Sequence | TPKAKLEAQEMPSQLFTLGA SEHSPLKTPYFDAGASCTEQ EMPRYHELPTLEERSGPLHP GATSLGSPIPVPPGPPAVED VSLDLEDEEGEEEEEYLDKI NPIYDALSYSSPSDSYQGKG FVMSRAMYV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 410-538 of human Nectin 2/CD112 (ARC1665). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebNectin Cell Adhesion Molecule 2Poliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nectin-2 antibodyAnti-Herpes Virus Entry Mediator B antibodyAnti-Herpesvirus Entry Mediator B antibodyAnti-Hveb antibodyAnti-Nectin Cell Adhesion Molecule 2 antibodyAnti-Poliovirus Receptor-Related Protein 2 antibodyAnti-Cd Antigen Cd112 antibodyAnti-NECTIN2 antibodyAnti-HVEB antibodyAnti-PRR2 antibodyAnti-PVRL2 antibody |
Information sourced from Uniprot.org