| Host: | Rat |
| Applications: | IHC-F/FC/ELISA/IF/IP |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rat monoclonal antibody anti-Nectin-3 is suitable for use in Immunohistochemistry, Flow Cytometry, ELISA, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 103-A1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration: | 100 ug/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | NECTIN3 |
| Gene ID: | 25945 |
| Uniprot ID: | NECT3_HUMAN |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| Function | Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Plays a role in the morphology of the ciliary body. |
| Protein Name | Nectin-3 Cdw113 Nectin Cell Adhesion Molecule 3 Poliovirus Receptor-Related Protein 3 Cd Antigen Cd113 |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-420597 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Postsynaptic Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Adherens Junction In The Auditory Epithelium Specificaly Localizes To The Apical Side Of The Lateral Membranes Of Supporting Cells |
| Alternative Antibody Names | Anti-Nectin-3 antibody Anti-Cdw113 antibody Anti-Nectin Cell Adhesion Molecule 3 antibody Anti-Poliovirus Receptor-Related Protein 3 antibody Anti-Cd Antigen Cd113 antibody Anti-NECTIN3 antibody Anti-PRR3 antibody Anti-PVRL3 antibody |
Information sourced from Uniprot.org