| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NECAB3 (1-362) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NECAB3 |
| Gene ID: |
63941 |
| Uniprot ID: |
NECA3_HUMAN |
| Immunogen Region: |
1-362 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-362 of human NECAB3 (NP_112508.3). |
| Immunogen Sequence: |
MACAGLLTVCLLRPPAPQPQ PQTPRHPQLAPDPGPAGHTL FQDVFRRADKNDDGKLSFEE FQNYFADGVLSLGELQELFS GIDGHLTDNLETEKLCDYFS EHLGVYRPVLAALESLNRAV LAAMDATKLEYERASKVDQF VTRFLLRETVSQLQALQSSL EGASDTLEAQAHGWRSDAES VEAQSRLCGSRRAGRRALRS VSRSSTWSPGSSDTGRSSEA EMQWRLQVNRLQELIDQLE |
| Tissue Specificity | Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. |
| Post Translational Modifications | Phosphorylated by NEK2. |
| Function | Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions.the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. |
| Protein Name | N-Terminal Ef-Hand Calcium-Binding Protein 3Amyloid-Beta A4 Protein-Binding Family A Member 2-Binding ProteinNek2-Interacting Protein 1Neuronal Calcium-Binding Protein 3X11l-Binding Protein 51 |
| Cellular Localisation | Golgi Apparatus |
| Alternative Antibody Names | Anti-N-Terminal Ef-Hand Calcium-Binding Protein 3 antibodyAnti-Amyloid-Beta A4 Protein-Binding Family A Member 2-Binding Protein antibodyAnti-Nek2-Interacting Protein 1 antibodyAnti-Neuronal Calcium-Binding Protein 3 antibodyAnti-X11l-Binding Protein 51 antibodyAnti-NECAB3 antibodyAnti-APBA2BP antibodyAnti-NIP1 antibodyAnti-SYTIP2 antibodyAnti-XB51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
