Anti-NDUFS2 antibody (300-407 aa) [R08-4D7] (STJA0012488)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human NDUFS2
General Information
| Short Description | Rabbit monoclonal anti-NDUFS2 (300-407 aa) for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-4D7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4ยฐC short term. Aliquot and store at-20ยฐC long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | NDUFS2 |
| Gene ID | 4720 |
| Uniprot ID | NDUS2_HUMAN |
| Immunogen | Recombinant protein of human NDUFS2 |
| Immunogen Region | 300-407 aa |
Additional Info
| Post Translational Modifications | Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex. |
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I. Essential for the assembly of complex I. Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction. Plays an important role in carotid body sensing of hypoxia. Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation. |
| Protein Name | Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - MitochondrialComplex I-49kdCi-49kdNadh-Ubiquinone Oxidoreductase 49 Kda Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-6799198 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Nadh Dehydrogenase Ubiquinone Iron-Sulfur Protein 2 - Mitochondrial antibodyAnti-Complex I-49kd antibodyAnti-Ci-49kd antibodyAnti-Nadh-Ubiquinone Oxidoreductase 49 Kda Subunit antibodyAnti-NDUFS2 antibody |
Information sourced from Uniprot.org