Function | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. |
Protein Name | Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 3Glucosaminyl N-Deacetylase/N-Sulfotransferase 3Ndst-3Hndst-3N-Heparan Sulfate Sulfotransferase 3N-Hsst 3 Includes - Heparan Sulfate N-Deacetylase Ndst3 - Heparan Sulfate-Glucosamine N-Sulfotransferase Ndst3 |
Database Links | Reactome: R-HSA-2022928 |
Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
Alternative Antibody Names | Anti-Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 3 antibodyAnti-Glucosaminyl N-Deacetylase/N-Sulfotransferase 3 antibodyAnti-Ndst-3 antibodyAnti-Hndst-3 antibodyAnti-N-Heparan Sulfate Sulfotransferase 3 antibodyAnti-N-Hsst 3 Includes - Heparan Sulfate N-Deacetylase Ndst3 - Heparan Sulfate-Glucosamine N-Sulfotransferase Ndst3 antibodyAnti-NDST3 antibodyAnti-HSST3 antibodyAnti-UNQ2544 antibodyAnti-PRO4998 antibody |
Information sourced from Uniprot.org