| Tissue Specificity | Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain. |
| Function | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Protein Name | NorrinNorrie Disease ProteinX-Linked Exudative Vitreoretinopathy 2 Protein |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Norrin antibodyAnti-Norrie Disease Protein antibodyAnti-X-Linked Exudative Vitreoretinopathy 2 Protein antibodyAnti-NDP antibodyAnti-EVR2 antibody |
Information sourced from Uniprot.org
