| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Necdin (101-151 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NDN |
| Gene ID: | 4692 |
| Uniprot ID: | NECD_HUMAN |
| Immunogen Region: | 101-151 aa |
| Specificity: | This antibody detects endogenous levels of human NECD |
| Immunogen: | Synthesized peptide derived from the human NECD at the amino acid range 101-151 |
| Function | Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences. |
| Protein Name | Necdin |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | PerikaryonNucleusNeural PerikaryaTranslocates To The Nucleus Of Postmitotic Neurons And Interacts With The Nuclear Matrix |
| Alternative Antibody Names | Anti-Necdin antibodyAnti-NDN antibody |
Information sourced from Uniprot.org