| Host: |
Rabbit |
| Applications: |
IHC/IF/WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Nuclear receptor corepressor 2 (511-560 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NCOR2 |
| Gene ID: |
9612 |
| Uniprot ID: |
NCOR2_HUMAN |
| Immunogen Region: |
511-560 aa |
| Specificity: |
SMRTe Polyclonal Antibody detects endogenous levels of SMRTe protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human NCOR2 at the amino acid range 511-560 |
| Function | Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Isoform 1: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Isoform 4: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. |
| Protein Name | Nuclear Receptor Corepressor 2N-Cor2Ctg Repeat Protein 26Smap270Silencing Mediator Of Retinoic Acid And Thyroid Hormone ReceptorSmrtT3 Receptor-Associating FactorTracThyroid- - Retinoic-Acid-Receptor-Associated Corepressor |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9623433Reactome: R-HSA-9707564 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 2 antibodyAnti-N-Cor2 antibodyAnti-Ctg Repeat Protein 26 antibodyAnti-Smap270 antibodyAnti-Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor antibodyAnti-Smrt antibodyAnti-T3 Receptor-Associating Factor antibodyAnti-Trac antibodyAnti-Thyroid- - Retinoic-Acid-Receptor-Associated Corepressor antibodyAnti-NCOR2 antibodyAnti-CTG26 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
