| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCF2 |
| Gene ID: | 4688 |
| Uniprot ID: | NCF2_HUMAN |
| Immunogen Region: | 227-526 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 227-526 of human NOXA2/p67phox (NP_000424.2). |
| Immunogen Sequence: | PPPRPKTPEIFRALEGEAHR VLFGFVPETKEELQVMPGNI VFVLKKGNDNWATVMFNGQK GLVPCNYLEPVELRIHPQQQ PQEESSPQSDIPAPPSSKAP GRPQLSPGQKQKEEPKEVKL SVPMPYTLKVHYKYTVVMKT QPGLPYSQVRDMVSKKLELR LEHTKLSYRPRDSNELVPLS EDSMKDAWGQVKNYCLTLWC ENTVGDQGFPDEPKESEKAD ANNQTTEPQLKKGSQVEAL |
| Function | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. |
| Protein Name | Neutrophil Cytosol Factor 2Ncf-267 Kda Neutrophil Oxidase FactorNadph Oxidase Activator 2Neutrophil Nadph Oxidase Factor 2P67-Phox |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1236973Reactome: R-HSA-3299685Reactome: R-HSA-4420097Reactome: R-HSA-5668599Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Neutrophil Cytosol Factor 2 antibodyAnti-Ncf-2 antibodyAnti-67 Kda Neutrophil Oxidase Factor antibodyAnti-Nadph Oxidase Activator 2 antibodyAnti-Neutrophil Nadph Oxidase Factor 2 antibodyAnti-P67-Phox antibodyAnti-NCF2 antibodyAnti-NOXA2 antibodyAnti-P67PHOX antibody |
Information sourced from Uniprot.org
