Anti-NAT8 antibody (61-220) (STJ110070)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NAT8 (61-220) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAT8 |
| Gene ID | 9027 |
| Uniprot ID | NAT8_HUMAN |
| Immunogen Region | 61-220 |
| Immunogen Sequence | LLALVFSISLFPALWFLAKK PWTEYVDMTLCTDMSDITKS YLSERGSCFWVAESEEKVVG MVGALPVDDPTLREKRLQLF HLFVDSEHRRQGIAKALVRT VLQFARDQGYSEVILDTGTI QLSAMALYQSMGFKKTGQSF FCVWARLVALHTVHFIYHLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 61-220 of human NAT8 (Q9UHE5). |
Additional Info
| Tissue Specificity | Preferentially expressed in liver and kidney. Also detected in brain (at protein level). |
| Function | Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. N(6)-lysine acetylation in the ER maintains protein homeostasis and regulates reticulophagy. Alternatively, acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. |
| Protein Name | N-Acetyltransferase 8Acetyltransferase 2Atase2Camello-Like Protein 1Cysteinyl-Conjugate N-AcetyltransferaseCcnatProtein-Lysine N6-Acetyltransferase 8 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-N-Acetyltransferase 8 antibodyAnti-Acetyltransferase 2 antibodyAnti-Atase2 antibodyAnti-Camello-Like Protein 1 antibodyAnti-Cysteinyl-Conjugate N-Acetyltransferase antibodyAnti-Ccnat antibodyAnti-Protein-Lysine N6-Acetyltransferase 8 antibodyAnti-NAT8 antibodyAnti-CML1 antibodyAnti-GLA antibodyAnti-TSC501 antibody |
Information sourced from Uniprot.org