| Tissue Specificity | Ubiquitous. |
| Function | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has N-acetylmannosamine (ManNAc) kinase activity. Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2. |
| Protein Name | N-Acetyl-D-Glucosamine KinaseN-Acetylglucosamine KinaseGlcnac KinaseMuramyl Dipeptide KinaseN-Acetyl-D-Mannosamine Kinase |
| Database Links | Reactome: R-HSA-446210 |
| Alternative Antibody Names | Anti-N-Acetyl-D-Glucosamine Kinase antibodyAnti-N-Acetylglucosamine Kinase antibodyAnti-Glcnac Kinase antibodyAnti-Muramyl Dipeptide Kinase antibodyAnti-N-Acetyl-D-Mannosamine Kinase antibodyAnti-NAGK antibody |
Information sourced from Uniprot.org
