| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NACC1 (170-340) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NACC1 |
| Gene ID: |
112939 |
| Uniprot ID: |
NACC1_HUMAN |
| Immunogen Region: |
170-340 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-340 of human NACC1 (NP_443108.1). |
| Immunogen Sequence: |
QQESDSVQCMPVAKRLWDSG QKEAGGGGNGSRKMAKFSTP DLAANRPHQPPPPQQAPVVA AAQPAVAAGAGQPAGGVAAA GGVVSGPSTSERTSPGTSSA YTSDSPGSYHNEEDEEEDGG EEGMDEQYRQICNMYTMYSM MNVGQTAEKVEALPEQVAPE SRNRIRVRQDL |
| Tissue Specificity | Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. |
| Function | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. |
| Protein Name | Nucleus Accumbens-Associated Protein 1Nac-1Btb/Poz Domain-Containing Protein 14b |
| Cellular Localisation | NucleusCytoplasmDistribution In The Cytoplasm Is Dependent On Phosphorylation |
| Alternative Antibody Names | Anti-Nucleus Accumbens-Associated Protein 1 antibodyAnti-Nac-1 antibodyAnti-Btb/Poz Domain-Containing Protein 14b antibodyAnti-NACC1 antibodyAnti-BTBD14B antibodyAnti-NAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
