| Short Description : | Rabbit monoclonal Nascent Polypeptide-Associated Complex Subunit Alpha (1-215) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4738RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:2000-1:20000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NACA |
| Gene ID: | 4666 |
| Uniprot ID: | NACA_HUMAN |
| Immunogen Region: | 1-215 |
| Immunogen Sequence: | MPGEATETVPATEQELPQPQ AETGSGTESDSDESVPELEE QDSTQATTQQAQLAAAAEID EEPVSKAKQSRSEKKARKAM SKLGLRQVTGVTRVTIRKSK NILFVITKPDVYKSPASDTY IVFGEAKIEDLSQQAQLAAA EKFKVQGEAVSNIQENTQTP TVQEESEEEEVDETGVEVKD IELVMSQANVSRAKAVRALK NNSNDIVNAIMELTM |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NACA (NP_005585.1). |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. |
| Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. |
| Protein Name | Nascent Polypeptide-Associated Complex Subunit AlphaNac-AlphaAlpha-NacAllergen Hom S 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusThe Heterodimer Is Located Mainly In The CytosolAnd The Homodimer In The Nucleus |
| Alternative Antibody Names | Anti-Nascent Polypeptide-Associated Complex Subunit Alpha antibodyAnti-Nac-Alpha antibodyAnti-Alpha-Nac antibodyAnti-Allergen Hom S 2 antibodyAnti-NACA antibodyAnti-HSD48 antibody |
Information sourced from Uniprot.org
