| Tissue Specificity | Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. |
| Post Translational Modifications | Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment. |
| Function | Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. |
| Protein Name | N-Alpha-Acetyltransferase 15 - Nata Auxiliary SubunitGastric Cancer Antigen Ga19N-Terminal AcetyltransferaseNmda Receptor-Regulated Protein 1Protein Tubedown-1Tbdn100 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusMainly CytoplasmicNuclear In Some CasesPresent In The Free Cytosolic And Cytoskeleton-Bound PolysomesBut Not In The Membrane-Bound Polysomes |
| Alternative Antibody Names | Anti-N-Alpha-Acetyltransferase 15 - Nata Auxiliary Subunit antibodyAnti-Gastric Cancer Antigen Ga19 antibodyAnti-N-Terminal Acetyltransferase antibodyAnti-Nmda Receptor-Regulated Protein 1 antibodyAnti-Protein Tubedown-1 antibodyAnti-Tbdn100 antibodyAnti-NAA15 antibodyAnti-GA19 antibodyAnti-NARG1 antibodyAnti-NATH antibodyAnti-TBDN100 antibody |
Information sourced from Uniprot.org
