Anti-MZB1 antibody (1-189) (STJ116689)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MZB1 (1-189) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MZB1 |
| Gene ID | 51237 |
| Uniprot ID | MZB1_HUMAN |
| Immunogen Region | 1-189 |
| Immunogen Sequence | MRLSLPLLLLLLGAWAIPGG LGDRAPLTATAPQLDDEEMY SAHMPAHLRCDACRAVAYQM WQNLAKAETKLHTSNSGGRR ELSELVYTDVLDRSCSRNWQ DYGVREVDQVKRLTGPGLSE GPEPSISVMVTGGPWPTRLS RTCLHYLGEFGEDQIYEAHQ QGRGALEALLCGGPQGACSE KVSATREEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human MZB1 (NP_057543.2). |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. |
| Post Translational Modifications | Forms an interchain disulfide bond with IgM monomers. |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
| Protein Name | Marginal Zone B- And B1-Cell-Specific ProteinMesenteric Estrogen-Dependent Adipose 7Meda-7Plasma Cell-Induced Resident Endoplasmic Reticulum ProteinPlasma Cell-Induced Resident Er ProteinPerp1Proapoptotic Caspase Adapter Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum LumenSecretedIsoform 2: CytoplasmDiffuse Granular Localization In The Cytoplasm Surrounding The Nucleus |
| Alternative Antibody Names | Anti-Marginal Zone B- And B1-Cell-Specific Protein antibodyAnti-Mesenteric Estrogen-Dependent Adipose 7 antibodyAnti-Meda-7 antibodyAnti-Plasma Cell-Induced Resident Endoplasmic Reticulum Protein antibodyAnti-Plasma Cell-Induced Resident Er Protein antibodyAnti-Perp1 antibodyAnti-Proapoptotic Caspase Adapter Protein antibodyAnti-MZB1 antibodyAnti-MEDA7 antibodyAnti-PACAP antibodyAnti-HSPC190 antibody |
Information sourced from Uniprot.org