Anti-MYSM1 antibody (520-569) (STJ94322)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
General Information
| Short Description | Rabbit polyclonal anti-Deubiquitinase MYSM1 (520-569) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYSM1 |
| Gene ID | 114803 |
| Uniprot ID | MYSM1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569 |
| Immunogen Region | 520-569 |
| Specificity | MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein. |
Additional Info
| Function | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome. |
| Protein Name | Deubiquitinase Mysm12a-DubMyb-Like - Swirm And Mpn Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm In Response To Bacterial Infection |
| Alternative Antibody Names | Anti-Deubiquitinase Mysm1 antibodyAnti-2a-Dub antibodyAnti-Myb-Like - Swirm And Mpn Domain-Containing Protein 1 antibodyAnti-MYSM1 antibodyAnti-KIAA1915 antibody |
Information sourced from Uniprot.org