| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Myod1 (1-318) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Myod1 |
| Gene ID: |
17927 |
| Uniprot ID: |
MYOD1_MOUSE |
| Immunogen Region: |
1-318 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of mouse Myod1 (NP_034996.2) |
| Immunogen Sequence: |
MELLSPPLRDIDLTGPDGSL CSFETADDFYDDPCFDSPDL RFFEDLDPRLVHMGALLKPE EHAHFPTAVHPGPGAREDEH VRAPSGHHQAGRCLLWACKA CKRKTTNADRRKAATMRERR RLSKVNEAFETLKRCTSSNP NQRLPKVEILRNAIRYIEGL QALLRDQDAAPPGAAAFYAP GPLPPGRGSEHYSGDSDASS PRSNCSDGMMDYSGPPSGPR RQNGYDTAYYSEAARESRP |
| Post Translational Modifications | Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. Ubiquitinated on the N-terminus.which is required for proteasomal degradation. Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation. Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity. |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. |
| Protein Name | Myoblast Determination Protein 1 |
| Database Links | Reactome: R-MMU-525793 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Myoblast Determination Protein 1 antibodyAnti-Myod1 antibodyAnti-Myod antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
